Akt1, Akt2 and Akt3 isoforms have distinct physiological roles this could also be the case during decidualization and pregnancy. It has been well demonstrated previously that Akt is importantly involved in cell survival and glycogen synthesis. Intracellular and molecular mechanisms involved in the regulation of apoptosis and cell proliferation during decidualization of the endometrium are yet to be fully understood. In order to allow for this window of implantation to be open at the right moment, endometrial stromal cells proliferate and differentiate by a mechanism called decidualization. It is thought that infertility can emanate from the dysregulated communication between the embryo and the maternal endometrium. Abstract Infertility is constantly increasing in Canada, where 16% of Canadian couples are experiencing difficulty conceiving.
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